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Survodutide

Survodutide

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What is Survodutide?

Survodutide (BI 456906) is an investigational dual GLP‑1/glucagon receptor agonist under development for obesity and metabolic liver disease In phase 2 trials, once‑weekly subcutaneous dosing (0.6–4.8 mg) produced dose‑dependent weight loss of 12.5–14.9% versus placebo over 46 weeks.

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Description

How This Works

Observations from clinical literature.

  • Dose‑dependent weight loss of 12.5–14.9% (vs placebo) over 46 weeks in phase 2 obesity trials.
  • Improvements in liver‑related biomarkers in NAFLD/NASH populations.
  • Meta‑analysis confirms consistent weight‑loss efficacy across multiple randomized controlled trials.
  • Adverse effects are primarily gastrointestinal: nausea, vomiting, diarrhea, and constipation (most common during dose escalation).
  • Gradual titration helps mitigate GI tolerability issues.

Details

Intended Use: MOTS-c is designed for Research Purposes only.

Storage: Store the vial in a cool, dry place away from direct sunlight. Once reconstituted, keep refrigerated at 2-8°C.

Solubility: Reconstitute with bacteriostatic water for best results.

Shelf Life: The lyophilized form has a shelf life of 24 months when properly stored. Once reconstituted, refrigerate and use within 4-6 weeks.

Handling: Ensure sterile techniques are used to maintain the product’s integrity during research.

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